Article
Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence.
Cancer cell - 12 Jan 2026
Piyadasa Hadeesha, Oberlton Benjamin, Ribi Mikaela, Leow Ke, Ranek Jolene S, Averbukh Inna, Amouzgar Meelad, Liu Candace C, Franchina Davide G, Greenwald Noah F, McCaffrey Erin F, Kumar Rashmi, Ferrian Selena, Tsai Albert G, Filiz Ferda, Fullaway Christine Camacho, Bosse Marc, Varra Sricharan Reddy, Kong Alex, Sowers Cameron, Gephart Melanie Hayden, Nuñez-Perez Pablo, Yang EnJun, Travers Mike, Schachter Michael J, Liang Samantha, Santi Maria R, Bucktrout Samantha, Gherardini Pier Federico, Connolly John, Cole Kristina, Barish Michael E, Brown Christine E, Oldridge Derek A, Drake Richard R, Phillips Joanna J, Okada Hideho, Prins Robert, Bendall Sean C, Angelo Michael
Abstract excerpt
Gliomas are among the most lethal cancers, with limited treatment options. To uncover hallmarks of therapeutic escape and tumor microenvironment (TME) landscape, we applied spatial proteomics, transcriptomics, and glycomics to 670 lesions from 310 adult and pediatric patients. Single-cell analysis shows high B7H3+ tumor cell prevalence in glioblastoma (GBM) and pleomorphic xanthoastrocytoma, while most gliomas,...
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