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A living pediatric brain tumor atlas reveals histomolecular diversity and therapeutic vulnerabilities for precision neuro-oncology

2026-08-14

Abstract excerpt

<title>Abstract</title> <p>Molecular classification has transformed pediatric brain tumor diagnosis but provides only a static view of highly dynamic diseases, overlooking tumor evolution, intra-tumoral heterogeneity, and functional therapeutic vulnerabilities. We established a living pediatric brain tumor atlas by prospectively generating patient-derived cell lines (PDCLs) and xenografts (PDXs) from 118 pediatri...

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Literature Corpus work
b0cb4eba-f9ba-575e-8d3f-850f41b38188
DOI
10.21203/rs.3.rs-10438673/v1
Open publication

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