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Uncovering Ethnicity-Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family-Based WGS Analysis.

Genetic epidemiology - 1 Jul 2025

Lee Sanghun, Hecker Julian, Vardarajan Badri N, Kelly Rachel S, Prince Nicole, Mullin Kristina, Lutz Sharon M, Hahn Georg, Lasky-Su Jessica, Mayeux Richard P, Tanzi Rudolph E, Lange Christoph, Prokopenko Dmitry

Abstract excerpt

In a sample of 89 Dominican families from the National Institute on Aging's Alzheimer's Disease Sequencing Project (ADSP), where at least one family member had a confirmed Alzheimer's disease (AD) diagnosis, we conducted an exploratory recessive whole-genome sequencing (WGS) analysis using family-based association testing (FBAT-GEE). This method tests jointly for affection status and age-at-onset under a...

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PMID: 40488219
DOI: 10.1002/gepi.70014

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PDK2
MAPT

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