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Article

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Willett Julian Daniel Sunday, Waqas Mohamad, Naumenko Serhiy, Mullin Kristina, Hecker Julian, Bertram Lars, Lange Christoph, Vlachos Ioannis, Hide Winston, Tanzi Rudolph E, Prokopenko Dmitry

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self-identifying as Hispanic. Population-specific results enable personalized and equitable interventions. Ethnicity as a stratifier co-occurs with genomic inflation due to heterogeneity. METHODS: We conducted genome-wide association studies (GWAS) and meta-analyses among...

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Source

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Identifiers

PMID: 41755704
DOI: 10.1002/alz.71189
PMCID: PMC12946819

Genes

ASPSCR1
GDAP2
PIEZO2
PSEN1
RGS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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