Back to search

Article

Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer’s Disease-Associated Genes in the Hispanic Population

2025-01-19

Abstract excerpt

Alzheimer’s disease (AD) is the most common form of dementia in elderly, affecting 6.9 million individuals in the United States. Some studies have suggested the prevalence of AD is greater in individuals who self-identify as Hispanic. Focused results are relevant for personalized and equitable clinical interventions. Ethnicity as a stratifying tool in genetic studies is often accompanied by genomic inflation due t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
37c9479a-7aa4-5e5c-872f-8aad1dd59a7c
DOI
10.1101/2025.01.18.25320774
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer’s Disease-Associated Genes in the Hispanic PopulationDOI 10.1101/2025.01.18.25320774
Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.Semantic proximity
Multivariate genotypic analyses that identify specific genotypes to characterize disease and control groups in ADNISemantic proximity
Assessment of common genetic variation in Alzheimer’s and Parkinson’s diseases reveals global distinction in population attributable riskSemantic proximity
Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing ProjectSemantic proximity
Identifying Individuals at High Risk for Alzheimer’s Disease Among Hispanics Using Single and Multi-Ancestry Polygenic Risk ScoresSemantic proximity
Polygenic Risk Scores for Alzheimer’s Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos – Investigation of Neurocognitive AgingSemantic proximity
Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project.Semantic proximity
The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.Semantic proximity
Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium StudySemantic proximity
Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s DiseaseSemantic proximity
Genetic Contributions to Alzheimer’s Disease and Frontotemporal Dementia in Admixed Latin American PopulationsSemantic proximity
First GWAS on Alzheimer’s Disease in Argentina and Chile populationsSemantic proximity
Select a neighboring publication to make it the new centre.