Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.

doi:10.1016/j.neurobiolaging.2021.02.019

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Article

Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.

Neurobiology of aging - 1 Aug 2021

Rajabli Farid, Feliciano-Astacio Briseida E, Cukier Holly N, Wang Liyong, Griswold Anthony J, Hamilton-Nelson Kara L, Adams Larry D, Rodriguez Vanessa C, Mena Pedro R, Tejada Sergio, Celis Katrina, Whitehead Patrice L, Van Booven Derek J, Hofmann Natalia K, Bussies Parker L, Prough Michael, Chinea Angel, Feliciano Nereida I, Vardarajan Badri N, Reitz Christiane, Lee Joseph H, Prince Martin J, Jimenez Ivonne Z, Mayeux Richard P, Acosta Heriberto, Dalgard Clifton L, Haines Jonathan L, Vance Jeffery M, Cuccaro Michael L, Beecham Gary W, Pericak-Vance Margaret A

Abstract excerpt

The genetic admixture of Caribbean Hispanics provides an opportunity to discover novel genetic factors in Alzheimer disease (AD). We sought to identify genetic variants for AD through a family-based design using the Puerto Rican (PR) Alzheimer Disease Initiative (PRADI). Whole-genome sequencing (WGS) and parametric linkage analysis were performed for 100 individuals from 23 multiplex PRADI families. Variants were...

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PMID: 33902942
DOI: 10.1016/j.neurobiolaging.2021.02.019
PMCID: PMC8851406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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