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Article

Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1.

Molecular psychiatry - 1 Jun 2022

Kizil Caghan, Sariya Sanjeev, Kim Yoon A, Rajabli Farid, Martin Eden, Reyes-Dumeyer Dolly, Vardarajan Badri, Maldonado Aleyda, Haines Jonathan L, Mayeux Richard, Jiménez-Velázquez Ivonne Z, Santa-Maria Ismael, Tosto Giuseppe

Abstract excerpt

Late-onset Alzheimer's disease (LOAD) is significantly more frequent in Hispanics than in non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this end, we studied a large cohort of Caribbean Hispanics (CH, N = 8813) and tested the association between Local Ancestry (LA) and LOAD ("admixture mapping") to identify LOAD-associated ancestral blocks, separately for ancestral components...

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Identifiers

PMID: 35365809
DOI: 10.1038/s41380-022-01526-6
PMCID: PMC9167722

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