Article
Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.
Scientific reports - 19 Mar 2020
Prokopenko Dmitry, Hecker Julian, Kirchner Rory, Chapman Brad A, Hoffman Oliver, Mullin Kristina, Hide Winston, Bertram Lars, Laird Nan, DeMeo Dawn L, Lange Christoph, Tanzi Rudolph E
Abstract excerpt
With the advent of whole genome-sequencing (WGS) studies, family-based designs enable sex-specific analysis approaches that can be applied to only affected individuals; tests using family-based designs are attractive because they are completely robust against the effects of population substructure. These advantages make family-based association tests (FBATs) that use siblings as well as parents especially suited...
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