Article
Dissecting Alzheimer's disease heritability across populations.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026
Liu Shiying, Bush William S, Kunkle Brian W, Byrd Goldie S, Reitz Christiane, Tosto Giuseppe, Rajabli Farid, Caban-Holt Allison M, Cuccaro Michael, Starks Takiyah, Adams Larry D, Feliciano Briseida E, Akinyemi Rufus, Vance Jeffery M, Pericak-Vance Margaret, Haines Jonathan L, Crawford Dana C, Williams Scott M
Abstract excerpt
INTRODUCTION: Late-onset Alzheimer's disease (LOAD) is highly heritable; however, its estimated incidence across populations remains unclear. METHODS: We computed family-based heritability leveraging Alzheimer's Disease Sequencing Project pedigrees from non-Hispanic White (404 pedigrees), non-Hispanic Black (13 pedigrees), Dominican (100 pedigrees), and Dutch isolate (10 pedigrees), with four models incorporating...
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