Article

MRBEE: A novel bias-corrected multivariable Mendelian Randomization method

2023-01-12

Abstract excerpt

Mendelian randomization (MR) is an instrumental variable approach used to infer causal relationships between exposures and outcomes and can apply to summary data from genome-wide association studies (GWAS). Since GWAS summary statistics are subject to estimation errors, most existing MR approaches suffer from measurement error bias, whose scale and direction are influenced by weak instrumental variables and GWAS s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5d22f83-5c3c-5f06-814b-474fd8fd0f85
DOI: 10.1101/2023.01.10.523480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MRBEE: A novel bias-corrected multivariable Mendelian Randomization methodDOI 10.1101/2023.01.10.523480Read

MRBEE: A bias-corrected multivariable Mendelian randomization method.Semantic proximity Read

Bias correction for inverse variance weighting Mendelian randomization.Semantic proximity Read

A robust penalized-regression-based method for multivariable Mendelian randomization using GWAS summary statisticsSemantic proximity Read

A multivariable cis-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias.Semantic proximity Read

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Semantic proximity Read

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read

Causal effect heterogeneity estimation using summary statisticsSemantic proximity Read

Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model.Semantic proximity Read

Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseasesSemantic proximity Read

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related DiseasesSemantic proximity Read

[Mendelian randomization approach, used for causal inferences].Semantic proximity Read