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MRCIP: a robust Mendelian randomization method accounting for correlated and idiosyncratic pleiotropy.

Briefings in bioinformatics - 2 Sept 2021

Xu Siqi, Fung Wing Kam, Liu Zhonghua

Abstract excerpt

Mendelian randomization (MR) is a powerful instrumental variable (IV) method for estimating the causal effect of an exposure on an outcome of interest even in the presence of unmeasured confounding by using genetic variants as IVs. However, the correlated and idiosyncratic pleiotropy phenomena in the human genome will lead to biased estimation of causal effects if they are not properly accounted for. In this...

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Causality
Cholesterol, LDL
Computer Simulation
Coronary Artery Disease
Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Likelihood Functions

Mendelian Randomization Analysis

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PMID: 33704372
DOI: 10.1093/bib/bbab019

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