An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.

Abstract excerpt

Mendelian randomization (MR) is an effective approach for revealing causal risk factors that underpin complex traits and diseases. While MR has been more widely applied under two-sample settings, it is more promising to be used in one single large cohort given the rise of biobank-scale datasets that simultaneously contain genotype data, brain imaging data, and matched complex traits from the same individual....

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