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Article

ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.

Aging - 8 Jun 2020

Kuo Chia-Ling, Pilling Luke C, Atkins Janice L, Kuchel George A, Melzer David

Abstract excerpt

The Apolipoprotein E (APOE) e4 allele is associated with reduced longevity and increased Coronary Artery Disease (CAD) and Alzheimer's disease, with e4e4 having markedly larger effect sizes than e3e4. The e2 longevity promoting variant is less studied. We conducted a phenome-wide association study of ApoE e2e3 and e2e2 with aging phenotypes, to assess their potential as targets for anti-aging interventions. Data...

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Identifiers

PMID: 32511104
DOI: 10.18632/aging.103405
PMCID: PMC7343499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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