Article

<i>ApoE</i> e2 and aging-related outcomes in 379,000 UK Biobank participants

2020-02-13

Abstract excerpt

The Apolipoprotein E (APOE) e4 allele is associated with reduced longevity and increased Coronary Artery Disease (CAD) and Alzheimer’s disease, with e4e4 having markedly larger effect sizes than e3e4. The e2 longevity promoting variant is less studied. We conducted a phenome-wide association study of ApoE e2e3 and e2e2 with aging phenotypes, to assess their potential as targets for anti-aging interventions. Data w...

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Literature Corpus work: 7742e255-bf0d-52c3-a66f-2f7c961ab830
DOI: 10.1101/2020.02.12.20022459

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