Article

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of <i>KMT2A</i> -rearranged leukemia

2020-12-07

Abstract excerpt

<h4>Summary</h4> Infant ALL is a devastating malignancy caused by rearrangements of the KMT2A gene ( KMT2A-r ) in approximately 70% of patients. The outcome is dismal and younger age at diagnosis is associated with increased risk of relapse. To discover age-specific differences and critical drivers that mediate the poor outcome in KMT2A-r ALL, we subjected KMT2A-r leukemias and normal hematopoietic cells from...

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Literature Corpus work: 3d73b6b6-f47c-5315-bb65-ef53ea240671
DOI: 10.1101/2020.12.06.413930

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