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Article

Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia.

Nature communications - 13 Dec 2021

Benard Brooks A, Leak Logan B, Azizi Armon, Thomas Daniel, Gentles Andrew J, Majeti Ravindra

Abstract excerpt

The impact of clonal heterogeneity on disease behavior or drug response in acute myeloid leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features of clonality associated with clinical features and drug sensitivities. High variant allele frequency for 7 mutations (including NRAS and TET2) associate with dismal prognosis; elevated GATA2 variant allele frequency correlates with...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Drug Resistance, Neoplasm

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 34903734
DOI: 10.1038/s41467-021-27472-5
PMCID: PMC8669028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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