Article

Integrative functional genomics reveals transcriptional regulatory function of risk alleles for metabolic liver disease

2025-10-23

Abstract excerpt

<title>Abstract</title> <p> Genome-wide association studies (GWAS) have identified nearly 100 loci associated with metabolic dysfunction-associated steatotic liver disease (MASLD), but the molecular functions of these variant alleles remain elusive, particularly when they occur in non-coding regions. Here we profiled the chromatin accessibility landscape of liver nuclei from MASLD individuals, and demonstrated t...

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Literature Corpus work: 3f0539a4-1113-5b8c-b332-1b21077494ad
DOI: 10.21203/rs.3.rs-6984670/v1

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