Genetic effects on liver chromatin accessibility identify disease regulatory variants.

doi:10.1016/j.ajhg.2021.05.001

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Article

Genetic effects on liver chromatin accessibility identify disease regulatory variants.

American journal of human genetics - 1 Jul 2021

Currin Kevin W, Erdos Michael R, Narisu Narisu, Rai Vivek, Vadlamudi Swarooparani, Perrin Hannah J, Idol Jacqueline R, Yan Tingfen, Albanus Ricardo D'Oliveira, Broadaway K Alaine, Etheridge Amy S, Bonnycastle Lori L, Orchard Peter, Didion John P, Chaudhry Amarjit S, Innocenti Federico, Schuetz Erin G, Scott Laura J, Parker Stephen C J, Collins Francis S, Mohlke Karen L

Abstract excerpt

Identifying the molecular mechanisms by which genome-wide association study (GWAS) loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) help identify GWAS loci that may alter GWAS traits by modulating chromatin structure, but caQTLs have been identified in a limited set of human tissues. Here we mapped caQTLs in human liver tissue in 20 liver samples and identified...

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Identifiers

PMID: 34038741
DOI: 10.1016/j.ajhg.2021.05.001
PMCID: PMC8323023

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