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Article

Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.

American journal of human genetics - 8 Jan 2026

Alkhawaja Abdalla A, Currin Kevin W, Perrin Hannah J, Vadlamudi Swarooparani, Etheridge Amy S, Broadaway K Alaine, Cannon Gabrielle H, Anderson Carlton W, Moxley Anne H, Iuga Alina C, Schuetz Erin G, Innocenti Federico, Furey Terrence S, Mohlke Karen L

Abstract excerpt

The liver is a central regulator of cardiometabolic physiology, coordinating processes such as lipid and glucose metabolism, protein synthesis, and detoxification. Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with cardiometabolic traits, yet their molecular mechanisms in liver cell types remain unclear. Using multiome gene expression and accessible chromatin...

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Identifiers

PMID: 41338218
DOI: 10.1016/j.ajhg.2025.11.009
PMCID: PMC12805840

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ADAMTS12

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