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Article

Mapping the genetic architecture of gene expression in human liver.

PLoS biology - 6 May 2008

Schadt Eric E, Molony Cliona, Chudin Eugene, Hao Ke, Yang Xia, Lum Pek Y, Kasarskis Andrew, Zhang Bin, Wang Susanna, Suver Christine, Zhu Jun, Millstein Joshua, Sieberts Solveig, Lamb John, GuhaThakurta Debraj, Derry Jonathan, Storey John D, Avila-Campillo Iliana, Kruger Mark J, Johnson Jason M, Rohl Carol A, van Nas Atila, Mehrabian Margarete, Drake Thomas A, Lusis Aldons J, Smith Ryan C, Guengerich F Peter, Strom Stephen C, Schuetz Erin, Rushmore Thomas H, Ulrich Roger

Abstract excerpt

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits. Therefore, identifying the molecular phenotypes that vary in response to changes in DNA and that also associate with changes in disease traits has the potential to provide the functional information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18462017
DOI: 10.1371/journal.pbio.0060107
PMCID: PMC2365981

Genes

CELSR2
ERBB3
RPS26
SORT1

Provenance

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