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Article

Expanded chromatin accessibility mapping explains genetic variation associated with complex traits in liver.

American journal of human genetics - 5 Feb 2026

Wenz Brandon M, Dudek Max F, Ramdas Shweta, Creasy Kate Townsend, Xin Dong, Olthoff Kim M, Shaked Abraham, Rader Daniel J, Brown Christopher D, Voight Benjamin F

Abstract excerpt

Genome-wide association studies (GWASs) have identified thousands of loci associated with a variety of common, complex human traits. Recent efforts have focused on characterizing chromatin accessibility to discover regulatory elements that modify the expression of nearby genes, suggesting that trait associations are mediated through changes in gene regulation. Genetic variants associated with differences in...

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Identifiers

PMID: 41650936
DOI: 10.1016/j.ajhg.2026.01.003
PMCID: PMC13012615

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