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Article

Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease.

Nature genetics - 1 Jun 2026

Zhu Biying, He Na, Xiao Yang, Chen Bin, Li Chen, Mandla Ravi, Liu Yifan, Zhang Jiayu, Chang Xiao, Yu Fulong, Vujkovic Marijana, Lynch Julie A, Chang Kyong-Mi, Pasaniuc Bogdan, Rader Daniel J, Lazar Mitchell A, Hu Wenxiang

Abstract excerpt

Genome-wide association studies have identified >100 loci associated with metabolic dysfunction-associated steatotic liver disease (MASLD), yet the mechanisms by which noncoding variants alter disease risk remain unclear. Here we map chromatin accessibility in human MASLD liver nuclei, revealing enrichment of risk variants within cell-type-specific regulatory elements bound by lineage-determining transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42230773
DOI: 10.1038/s41588-026-02617-8

Genes

ANGPTL3
APOA5
LPL
SLC22A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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