Article
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias.
Science translational medicine - 7 May 2025
Venkatasubramanian Meenakshi, Schwartz Leya, Ramachandra Nandini, Bennett Joshua, Subramanian Krithika R, Chen Xiaoting, Gordon-Mitchell Shanisha, Fromowitz Ariel, Pradhan Kith, Shechter David, Sahu Srabani, Heiser Diane, Scherle Peggy, Chetal Kashish, Kulkarni Aishwarya, Lee Davy, Zhou Jeff, Myers Kasiani C, Tseng Elizabeth, Weirauch Matthew T, Grimes H Leighton, Starczynowski Daniel T, Verma Amit, Salomonis Nathan
Abstract excerpt
The role of splicing dysregulation in cancer is underscored by splicing factor mutations; however, its impact in the absence of such rare mutations remains poorly understood. Prompted by the finding that splicing uniquely resolved genetic subtypes of cancer, we developed an unsupervised computational workflow called OncoSplice to comprehensively define tumor molecular landscapes. In adult and pediatric acute...
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