Analysis of 3,760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes

Abstract excerpt

<h4>Background</h4> Rare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substantially contribute to the large heterogeneity of hematologic malignancies. However, their identification remains challenging. <h4>Methods</h4> To address this issue, we generated the largest dataset to date of matched whole genome sequencing and total RNA sequencing of hematol...

Topics

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• Enhancer of Zeste Homolog 2 Protein
• fms-Like Tyrosine Kinase 3
• Isocitrate Dehydrogenase
• Leukemia, Myeloid, Acute
• Repressor Proteins
• RNA Splice Sites
• RNA Splicing
• Splicing Factor U2AF

Identifiers and source

Literature Corpus work

670f6c87-4352-5dd7-a3e6-b58d6ce57393

DOI

10.1101/2023.08.08.23293420