Article
Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells.
Cell reports. Medicine - 21 Mar 2023
van der Werf Inge, Mondala Phoebe K, Steel S Kathleen, Balaian Larisa, Ladel Luisa, Mason Cayla N, Diep Raymond H, Pham Jessica, Cloos Jacqueline, Kaspers Gertjan J L, Chan Warren C, Mark Adam, La Clair James J, Wentworth Peggy, Fisch Kathleen M, Crews Leslie A, Whisenant Thomas C, Burkart Michael D, Donohoe Mary E, Jamieson Catriona H M
Abstract excerpt
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) generation in adults, splicing deregulation has not been extensively studied in pAML. Herein, we describe single-cell proteogenomics analyses, transcriptome-wide...
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