Article

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

2024-02-08

Abstract excerpt

<h4>ABSTRACT</h4> The role of splicing dysregulation in cancer is underscored by splicing factor mutations; however, its impact in the absence of such rare mutations is poorly understood. To reveal complex patient subtypes and putative regulators of pathogenic splicing in Acute Myeloid Leukemia (AML), we developed a new approach called OncoSplice. Among diverse new subtypes, OncoSplice identified a biphasic poor...

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Literature Corpus work: c90a2779-2591-5624-85e5-775e53f67565
DOI: 10.1101/2024.02.04.578798

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