Article
Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML.
Cell reports. Medicine - 20 Jan 2026
Huang Yue, Xiao Peifang, Qin Lei, Gao Li, Zhao Yang, Sui Jingru, Hu Wenting, Zhou Lei, Han Nan, Lv Xuan, Chen Kunying, Liu Yu, Lin Hanhong, Shen Shuhong, Abdel-Wahab Omar, Hu Shaoyan, Liu Zhaoqi, Wang Qianfei
Abstract excerpt
Despite improvements in pediatric acute myeloid leukemia (AML) prognosis, about 30% of patients relapse after initial chemotherapy and have poor survival. However, the genetic basis of resistance remains unclear for most patients. To better understand the mechanistic basis and overcome treatment resistance, we analyze RNA sequencing (RNA-seq) data from 702 pediatric AML patients. This effort uncovers a...
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