Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex landscape of alternative splicing in myeloid neoplasms.

Leukemia - 1 Apr 2021

Hershberger Courtney E, Moyer Devlin C, Adema Vera, Kerr Cassandra M, Walter Wencke, Hutter Stephan, Meggendorfer Manja, Baer Constance, Kern Wolfgang, Nadarajah Niroshan, Twardziok Sven, Sekeres Mikkael A, Haferlach Claudia, Haferlach Torsten, Maciejewski Jaroslaw P, Padgett Richard A

Abstract excerpt

Myeloid neoplasms are characterized by frequent mutations in at least seven components of the spliceosome that have distinct roles in the process of pre-mRNA splicing. Hotspot mutations in SF3B1, SRSF2, U2AF1 and loss of function mutations in ZRSR2 have revealed widely different aberrant splicing signatures with little overlap. However, previous studies lacked the power necessary to identify commonly mis-spliced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Disease Susceptibility

Share to Loss of Function Mutation

Share to Myelodysplastic Syndromes

Share to Myeloproliferative Disorders

Share to RNA Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32753690
DOI: 10.1038/s41375-020-1002-y
PMCID: PMC8101081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex landscape of alternative splicing in myeloid neoplasms.PMID 32753690Read ↗

[RNA splicing dysregulation in hematological malignancies].Semantic proximity Read ↗

A Genome-Wide Aberrant RNA Splicing in Patients with Acute Myeloid Leukemia Identifies Novel Potential Disease Markers and Therapeutic TargetsSemantic proximity Read ↗

Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemiaSemantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

Aberrant RNA splicing and therapeutic opportunities in cancers.Semantic proximity Read ↗

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Therapeutic strategies targeting aberrant RNA splicing in myeloid malignancies.Semantic proximity Read ↗

Splicing dysregulation in human hematologic malignancies: beyond splicing mutations.Semantic proximity Read ↗

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms.Semantic proximity Read ↗

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Semantic proximity Read ↗

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Semantic proximity Read ↗

Splicing Factor Mutations in Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.