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Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome

16 Mar 2025

Abstract excerpt

ABSTRACT: The critical role of leukemia-initiating cells as a therapy-resistant population in myeloid leukemia is well established. However, the molecular signatures of such cells in acute lymphoblastic leukemia remain underexplored. Moreover, their role in therapy response and patient prognosis is yet to be systematically investigated across various types of acute leukemia. We used single-cell multiomics to...

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Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40089994
DOI: 10.1182/blood.2024027270

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