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UGT1A1 polymorphisms and metabolic phenotypes in indigenous peoples from the Brazilian Amazon.

Pharmacogenetics and genomics - 1 Jul 2025

Perini Jamila A, Dias Alessandra S, Gusmão Leonor, Skaf Larissa B, Elias Anna Beatriz R, Basta Paulo C, Carvalho Marcelo A, Suarez-Kurtz Guilherme

Abstract excerpt

OBJECTIVES: To explore the distribution of clinically relevant UGT1A1 polymorphisms and inferred UGT1A1 phenotypes in two Indigenous groups (Paiter-Suruí and Yanomami) from reservation areas in the Brazilian Amazon. METHODS: Ninety-two Yanomami and 88 Paiter-Suruí were genotyped with a validated panel of ancestry informative markers. Individuals with >90% Native ancestry were genotyped for the promoter TA repeat...

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PMID: 40277150
DOI: 10.1097/FPC.0000000000000566

Genes

UGT1A1

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