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Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.

Pharmacogenetics and genomics - 1 Aug 2013

Fohner Alison, Muzquiz LeeAnna I, Austin Melissa A, Gaedigk Andrea, Gordon Adam, Thornton Timothy, Rieder Mark J, Pershouse Mark A, Putnam Elizabeth A, Howlett Kevin, Beatty Patrick, Thummel Kenneth E, Woodahl Erica L

Abstract excerpt

OBJECTIVES: Cytochrome P450 enzymes play a dominant role in drug elimination and variation in these genes is a major source of interindividual differences in drug response. Little is known, however, about pharmacogenetic variation in American Indian and Alaska Native (AI/AN) populations. We have developed a partnership with the Confederated Salish and Kootenai Tribes (CSKT) in northwestern Montana to address this...

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PMID: 23778323
DOI: 10.1097/FPC.0b013e3283629ce9
PMCID: PMC3937472

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