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Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon.

Pharmacogenetics and genomics - 1 Oct 2020

Ferreira Guilherme Motta Antunes, Ribeiro Elias Anna Beatriz, Nascimento Joabi, Monteiro Wuelton Marcelo, Melo Gisely Cardoso, Baia-da-Silva Djane Clarys, Lacerda Marcus Vinícius Guimarães, Suarez-Kurtz Guilherme

Abstract excerpt

Reduced function alleles in the TPMT and NUDT15 genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT (rs1142345, rs1800460 and rs1800462) and NUDT15 (rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon. The average proportion of Native and European ancestry differed greatly and...

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PMID: 32453263
DOI: 10.1097/FPC.0000000000000411

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