Global pharmacogenomics: distribution of CYP3A5 polymorphisms and phenotypes in the Brazilian population.

doi:10.1371/journal.pone.0083472

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Article

Global pharmacogenomics: distribution of CYP3A5 polymorphisms and phenotypes in the Brazilian population.

PloS one - 1 Jan 2014

Suarez-Kurtz Guilherme, Vargens Daniela D, Santoro Ana Beatriz, Hutz Mara H, de Moraes Maria Elisabete, Pena Sérgio D J, Ribeiro-dos-Santos Ândrea, Romano-Silva Marco A, Struchiner Claudio José

Abstract excerpt

The influence of self-reported "race/color", geographical origin and genetic ancestry on the distribution of three functional CYP3A5 polymorphisms, their imputed haplotypes and inferred phenotypes was examined in 909 healthy, adult Brazilians, self-identified as White, Brown or Black ("race/color" categories of the Brazilian census). The cohort was genotyped for CYP3A5*3 (rs776746), CYP3A5*6 (rs10264272) and...

Topics

Alleles
Brazil
Cohort Studies
Cytochrome P-450 CYP3A
Ethnicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Frequency

Genotype

Haplotypes

Humans

Pharmacogenetics

Phenotype

Polymorphism, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 24427273
DOI: 10.1371/journal.pone.0083472
PMCID: PMC3888384

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