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Article

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico.

Pharmacogenomics - 1 Feb 2014

Lazalde-Ramos Blanca Patricia, Martínez-Fierro Margarita de la Luz, Galaviz-Hernández Carlos, Garza-Veloz Idalia, Naranjo María Eugenia G, Sosa-Macías Martha, Llerena Adrián

Abstract excerpt

AIM: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies in Mexican Mestizos. MATERIALS & METHODS: A total of 508 Amerindians were studied. Genotyping of CYP2D6*5 and multiplication alleles was performed by long-range PCR,...

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PMID: 24533713
DOI: 10.2217/pgs.13.203

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