Article
Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function.
Clinical and translational science - 1 Jul 2021
Fohner Alison E, Dalton Rachel, Skagen Kasse, Jackson Konner, Claw Katrina G, Hopkins Scarlett E, Robinson Renee, Khan Burhan A, Prasad Bhagwat, Schuetz Erin G, Nickerson Deborah A, Thornton Timothy A, Dillard Denise A, Boyer Bert B, Thummel Kenneth E, Woodahl Erica L
Abstract excerpt
The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet, the impact of genetic variants on enzyme activity are incompletely described, particularly in American Indian and Alaska...
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