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Article

Comprehensive profiling of cancer neoantigens from aberrant RNA splicing

1 May 2024

Abstract excerpt

BACKGROUND: Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkpoint inhibitors. We previously developed a computational framework, REAL-neo, for identification, quality control, and prioritization of both class-I and class-II human leucocyte antigen (HLA)-presented neoantigens...

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PMID: 38754917
DOI: 10.1136/jitc-2024-008988

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