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Article

Neoantigens in cancer immunotherapy: focusing on alternative splicing

11 Jul 2024

Abstract excerpt

Alternative splicing (AS) functions as a crucial program in transcriptional modulation, leading to proteomic diversity and functional alterations of proteins. These splicing actions induce various neoantigens that hold prognostic significance and contribute to various aspects of cancer progression, including immune responses against cancer. The advent of immunotherapy has remarkably revolutionized tumor therapy....

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PMID: 39055714
DOI: 10.3389/fimmu.2024.1437774

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