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Article

RNA Transcription and Splicing Errors as a Source of Cancer Frameshift Neoantigens for Vaccines

2 Oct 2019

Abstract excerpt

The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient's immune response to their tumor's neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vaccines based on sequencing the patient's tumor DNA to discover neoantigens. Here we propose an additional, unrecognized source of tumor neoantigens. We show that errors in...

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PMID: 31578439
DOI: 10.1038/s41598-019-50738-4

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