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Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens.

Cancer cell - 13 Aug 2018

Hoyos Luisa Escobar, Abdel-Wahab Omar

Abstract excerpt

In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens.

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Alternative Splicing
Antigens
Mutation
Neoplasms
RNA Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30107172
DOI: 10.1016/j.ccell.2018.07.008
PMCID: PMC6614861

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