Article

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

2023-10-20

Abstract excerpt

<h4>Summary</h4> T-cell-mediated immunotherapies are limited by the extent to which cancer-specific antigens are homogenously expressed throughout a tumor. We reasoned that recurrent splicing aberrations in cancer represent a potential source of tumor-wide and public neoantigens, and to test this possibility, we developed a novel pipeline for identifying neojunctions expressed uniformly within a tumor across dive...

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Literature Corpus work: b422baab-05fc-523f-aebf-dcf9e3cfe46c
DOI: 10.1101/2023.10.19.563178

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