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Article

Multiplex PCR for the Rapid Diagnosis of Myeloproliferative Neoplasms.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Semenuk Laura, Palazzolo Alissa, McCambridge Kristen, Wong Henry, Rauh Michael J, Feilotter Harriet, Quest Graeme

Abstract excerpt

Myeloproliferative neoplasms (MPN) develop as a disease of aging, due to the disruption of normal hematopoiesis, triggered by somatic mutations and a sustained inflammatory cycle. Driving variants within JAK2, MPL, and CALR are associated with various subtypes of MPN, with known targeted therapeutics and guided patient prognosis. Targeted clinical testing for the diagnosis of these precise driving variants within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40227493
DOI: 10.1007/7651_2025_625

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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