Article
Molecular diagnostic criteria of myeloproliferative neoplasms.
Expert review of molecular diagnostics - 1 Jan 2000
Andrews Claire, Conneally Eibhlin, Langabeer Stephen E
Abstract excerpt
INTRODUCTION: Myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell neoplasms characterized by the driver mutations JAK2, CALR, and MPL. These mutations cause constitutive activation of JAK-STAT signaling, which is central to pathogenesis of MPNs. Next-generation sequencing has further expanded the molecular landscape allowing for improved diagnostics, prognostication, and...
Topics
- Humans
- Pathology, Molecular
- Myeloproliferative Disorders
- Signal Transduction
- Mutation
- Genomics
- Neoplasms