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Article

Genomics of Myeloproliferative Neoplasms.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2017

Zoi Katerina, Cross Nicholas C P

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid leukemia. Deregulated JAK2 signaling has emerged as the central phenotypic driver of BCR -ABL1-negative MPNs and a unifying therapeutic target. In addition, MPNs show unexpected layers of genetic complexity,...

Topics

Genomics
Hematologic Neoplasms
Humans
Mutation
Myeloproliferative Disorders

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28297629
DOI: 10.1200/JCO.2016.70.7968

Genes

ABL1
BCR
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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