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An auxin-inducible degron system for conditional mutation in the fungal meningitis pathogen Cryptococcus neoformans.

G3 (Bethesda, Md.) - 4 Jun 2025

Huang Manning Y, Nalley Matthew J, Hecht Patrick C, Madhani Hiten D

Abstract excerpt

Cryptococcus neoformans is the top-ranked W.H.O. fungal priority pathogen, but tools for generating conditional mutations are limited. Auxin-inducible degron systems permit rapid and effective cellular depletion of a tagged protein of interest upon adding a small molecule. These tools are invaluable, particularly for studying essential genes, which may play important roles in pathogen biology. AID2 is one such...

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PMID: 40194515
DOI: 10.1093/g3journal/jkaf071
PMCID: PMC12134991

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