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Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

7 Apr 2015

Abstract excerpt

Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its overall biological and pathogenic regulatory circuits remain elusive, particularly due to the presence of an evolutionarily divergent set of transcription factors (TFs). Here, we report the construction of a high-quality library of 322 signature-tagged gene-deletion strains for 155 putative TF genes previously predicted using...

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PMID: 25849373
DOI: 10.1038/ncomms7757

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