Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An engineered mitoCBE facilitates efficient mitochondrial DNA editing and modified mitochondrial transfer.

Molecular therapy : the journal of the American Society of Gene Therapy - 2 Jul 2025

Liu Jie, Chen Jun, Huang Shisheng, Guo Junfan, Li Xiangyang, Yan Ying, Chen Ruijing, Li Guanglei, Liu Ming, Wei Jiao, Huang Xingxu, Qiao Yunbo

Abstract excerpt

Double-stranded DNA cytosine deaminase DddA orthologs from multiple types of bacteria have been fused with the transcription-activator-like effector system for mitochondrial DNA (mtDNA) base editing, while the efficiencies remain limited and its nuclear off-targeting activity cannot be ignored yet. Here we identified a DddA ortholog from Burkholderia gladioli (BgDddA) and generated nuclear or mtDNA cytosine base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Mitochondria

Share to Mutation

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 40181542
DOI: 10.1016/j.ymthe.2025.03.051
PMCID: PMC12266020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An engineered mitoCBE facilitates efficient mitochondrial DNA editing and modified mitochondrial transfer.PMID 40181542Read ↗

A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility.Semantic proximity Read ↗

Base editing in human cells with monomeric DddA-TALE fusion deaminases.Semantic proximity Read ↗

Advances in mitochondrial DNA base editing technology.Semantic proximity Read ↗

Unconstrained Precision Mitochondrial Genome Editing with αDdCBEsSemantic proximity Read ↗

Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED.Semantic proximity Read ↗

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors.Semantic proximity Read ↗

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNASemantic proximity Read ↗

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.Semantic proximity Read ↗

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNASemantic proximity Read ↗

Base editing of organellar DNA with programmable deaminases.Semantic proximity Read ↗

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases.Semantic proximity Read ↗

Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.