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Article

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases.

Nature communications - 19 Feb 2021

Lee Hyunji, Lee Seonghyun, Baek Gayoung, Kim Annie, Kang Beum-Chang, Seo Huiyun, Kim Jin-Soo

Abstract excerpt

DddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin DddAtox, transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI), enable targeted C-to-T base conversions in mitochondrial DNA (mtDNA). Here, we demonstrate highly efficient mtDNA editing in mouse embryos using custom-designed DdCBEs. We target the mitochondrial gene, MT-ND5 (ND5), which encodes a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33608520
DOI: 10.1038/s41467-021-21464-1
PMCID: PMC7895935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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