Article

Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patients

2021-10-04

Abstract excerpt

<h4>ABSTRACT</h4> B-cell acute lymphoblastic leukemia (B-ALL) is often driven by chromosome translocations that result in recurrent and well-studied gene fusions. Currently, fluorescent in-situ hybridization probes are employed to detect candidate translocations in bone marrow samples from B-ALL patients. Recently Hi-C, a sequencing-based technique originally designed to reconstruct the three-dimensional architect...

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Literature Corpus work: afa79bba-e720-52a9-9e7f-c59ba37ad23b
DOI: 10.1101/2021.10.01.21264442

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