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Article

Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking.

Blood advances - 23 Dec 2019

Lareau Caleb A, Ludwig Leif S, Sankaran Vijay G

Abstract excerpt

Our ability to track cellular dynamics in humans over time in vivo has been limited. Here, we demonstrate how somatic mutations in mitochondrial DNA (mtDNA) can be used to longitudinally track the dynamic output of hematopoietic stem and progenitor cells in humans. Over the course of 3 years of blood sampling in a single individual, our analyses reveal somatic mtDNA sequence variation and evolution reminiscent of...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31841597
DOI: 10.1182/bloodadvances.2019001196
PMCID: PMC6929387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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