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Article

Connecting MHC-I-binding motifs with HLA alleles via deep learning.

Communications biology - 18 Oct 2021

Lee Ko-Han, Chang Yu-Chuan, Chen Ting-Fu, Juan Hsueh-Fen, Tsai Huai-Kuang, Chen Chien-Yu

Abstract excerpt

The selection of peptides presented by MHC molecules is crucial for antigen discovery. Previously, several predictors have shown impressive performance on binding affinity. However, the decisive MHC residues and their relation to the selection of binding peptides are still unrevealed. Here, we connected HLA alleles with binding motifs via our deep learning-based framework, MHCfovea. MHCfovea expanded the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34663927
DOI: 10.1038/s42003-021-02716-8
PMCID: PMC8523706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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